تفاعل #76196

معادلة التفاعل

Carvedilol

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Carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

المذيبات

Hexane IPA

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby heating the mixture
2. 2
   أخرىto sit at room temperature
3. 3
   workup.STIRRINGwithout stirring for about 15 h
4. 4
   ترشيحthe resulting crystals were filtered through a buchner funnel
5. 5
   أخرىdried in a desiccator (connected to air pump) at room temperature until constant weight

الإجراء التجريبي

Carvedilol (4 g) was dissolved in 180 ml, Hexane/IPA in a ratio 1:1 by heating the mixture under stirring at 55° C. water bath. The solution was allowed to sit at room temperature without stirring for about 15 h, then the resulting crystals were filtered through a buchner funnel and dried in a desiccator (connected to air pump) at room temperature until constant weight to yield Carvedilol Form III.

المصدر