تفاعل #76195

معادلة التفاعل

Carvedilol

→

III

2-(2-Methoxyphenoxy)ethylamine

Carvedilol

II

4-(oxiran-2-ylmethoxy)-9H-carbazole

المذيبات

dioxane water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby heating the mixture
2. 2
   workup.WAITThe resulting solution was left at room temperature
3. 3
   workup.STIRRINGwithout stirring for about 15 h
4. 4
   ترشيحthe crystals were filtered through a buchner funnel
5. 5
   أخرىdried in a desiccator (connected to air pump) until constant weight

الإجراء التجريبي

Carvedilol (4 g) was dissolved in 267 mL dioxane/water in the ratio 1:1.4 respectively by heating the mixture under stirring at 55° C. water bath. The resulting solution was left at room temperature without stirring for about 15 h then the crystals were filtered through a buchner funnel and dried in a desiccator (connected to air pump) until constant weight to yield Carvedilol Form III in a mixture with Carvedilol Form II.

المصدر