تفاعل #76193

معادلة التفاعل

Carvedilol

water

→

Carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe solution was left at room temperature
2. 2
   workup.STIRRINGwithout stirring for about 80 h
3. 3
   ترشيحthe crystals were filtered through a buchner
4. 4
   أخرىdried in a desiccator at room temperature (connected to air pump) until constant weight

الإجراء التجريبي

Carvedilol (4 g) was dissolved in 39 mL pyridine by stirring at room temperature. 70 mL of water was then added dropwise until crystallization began. The solution was left at room temperature without stirring for about 80 h, then the crystals were filtered through a buchner and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield Carvedilol Form III.

المصدر