تفاعل #76192

معادلة التفاعل

Carvedilol

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carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

المذيبات

—

mixture

water methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby heating the mixture
2. 2
   درجة الحرارةThe solution cooled to ambient temperature
3. 3
   workup.WAITleft at ambient temperature
4. 4
   workup.STIRRINGwithout stirring for about 15 h
5. 5
   ترشيحthe crystals were filtered through a buchner
6. 6
   أخرىdried in a desiccator at room temperature (connected to air pump) until constant weight

الإجراء التجريبي

Carvedilol (4 g) was dissolved in 195 mL mixture of water/methanol (in a ratio 1:3 respectively) by heating the mixture under stirring in 55° C. water bath. The solution cooled to ambient temperature and left at ambient temperature without stirring for about 15 h, the crystals were filtered through a buchner and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.

المصدر