تفاعل #76191

معادلة التفاعل

Carvedilol

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carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

المذيبات

—

mixture

Ethanol

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby heating the mixture
2. 2
   درجة الحرارةThe solution was cooled
3. 3
   workup.WAITleft at room temperature
4. 4
   workup.STIRRINGwithout stirring for about 14 hours
5. 5
   ترشيحthe crystals were filtered through a buchner funnel
6. 6
   غسيلrinsed twice with about 10 ml cold (4° C.) 96% ethanol
7. 7
   أخرىdried in a desiccator at room temperature (connected to air pump) until constant weight

الإجراء التجريبي

Carvedilol (4 g) was dissolved in 45 mL of a mixture of 96% Ethanol and 4% water by heating the mixture under stirring in a 55° C. water bath. The solution was cooled and left at room temperature without stirring for about 14 hours, the crystals were filtered through a buchner funnel, rinsed twice with about 10 ml cold (4° C.) 96% ethanol, and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.

المصدر