تفاعل #76131

ord-d4a7a0d197a6451ba0b505edad115fdf

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    غسيلwashed with 5% aqueous sodium carbonate solution (2×100 ml), brine (100 ml)
  2. 2
    تركيزconcentrated in vacuo
  3. 3
    أخرىPurification by column chromatography
  4. 4
    غسيلon gradient elution with methanol in dichloromethane (0 to 2%)
  5. 5
    أخرىafforded a white crispy solid which
  6. 6
    أخرىwas triturated diethyl ether/hexanes (v/v, 1:2)
  7. 7
    ترشيحThe white solid was collected by filtration
  8. 8
    غسيلwashed with hexanes
  9. 9
    تجفيفdried in vacuo over P2O5 (0.202 g, 92%), mp 112-113° C.

الإجراء التجريبي

To a stirred under argon solution of tert-butyl 4-[N-[7-chloro-2-methanesulphonyloxymethyl-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate (0.230 g, 0.42 mmol) in anhydrous dichloromethane (10 ml) was added diethyl amine (0.306 g, 4.2 mmol). The yellow solution was then stirred at room temperature for 18 hours. The solution was then diluted with ethyl acetate (250 ml) and washed with 5% aqueous sodium carbonate solution (2×100 ml), brine (100 ml), and concentrated in vacuo. Purification by column chromatography, on gradient elution with methanol in dichloromethane (0 to 2%) afforded a white crispy solid which was triturated diethyl ether/hexanes (v/v, 1:2). The white solid was collected by filtration, washed with hexanes and dried in vacuo over P2O5 (0.202 g, 92%), mp 112-113° C.; 1H-NMR (DMSO-d6) 0.95 (t, J=6.9 Hz, 6H, 2×CH2CH3), 1.49 (s, 9H, But), 2.56 (q obscured, J=6.85 Hz, 4H, 2×CH2CH3), 3.62 (s, 3H, N3-Me), 3.70 (s, 2H, 2-CH2), 4.40 (s, 2H, CH2C≡C), 4.79 (s, 2H, 6-CH2), 6.78 (d, J=8.9 Hz, 2H, 3′,5′-ArH), 7.72 (d, J=8.9 Hz, 2′,6′-ArH), 7.81, 7.86 (2×s, 2H, 5-H, 8-H); MS (FAB, m/z) 523, 525 [(M+H)+, 100%, 40% respectively; Cl isotopic pattern].

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06699861B1uspto-grants-2004_03