تفاعل #76127

معادلة التفاعل

sodium

Chloroacetonitrile

2-amino-4-chloro-5-methylbenzoic acid

→

solid

المردود 69.0%

7-Chloro-2-chloromethyl-6-methyl-3,4-dihydroquinazolin-4-one

المردود 69.0%

المذيبات

methanol

MeOH

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 2 hours under argon
2. 2
   أخرىit was fitted with a condenser
3. 3
   أخرىplaced in an oil bath
4. 4
   أخرىpreheated to 80° C
5. 5
   workup.STIRRINGStirring
6. 6
   workup.WAITwas continued at this temperature for 2 hours under argon
7. 7
   درجة الحرارةto cool to room temperature
8. 8
   ترشيحThe precipitate was collected by filtration
9. 9
   غسيلwashed with methanol (10 ml), and water (10 ml)
10. 10
    تجفيفdried in vacuo over P2O5

الإجراء التجريبي

To a flask containing sodium (36 mg) was added anhydrous MeOH (5 ml). Chloroacetonitrile (0.520 g, 6.9 mmol) was then added and the clear solution was stirred at room temperature for 30 min under argon. A solution of 2-amino-4-chloro-5-methylbenzoic acid (1.13 g, 6.0 mmol) in anhydrous methanol (25 ml) was then added with a syringe via a rubber septum. The reaction mixture was stirred at room temperature for 2 hours under argon, then it was fitted with a condenser and placed in an oil bath preheated to 80° C. Stirring was continued at this temperature for 2 hours under argon, then the reaction mixture was allowed to cool to room temperature. The precipitate was collected by filtration, washed with methanol (10 ml), and water (10 ml), and dried in vacuo over P2O5 to afford a grey solid (1.0 g, 69%), mp 287-290° C.; 1H-NMR (DMSO-d6) 2.47 (s, 3H, 6-CH3), 4.53 (s, 2H, CH2Cl), 7.75, 8.08 (2×s, 2H, 5-H and 8-H); 12.60 (s, 1H, N3—H); MS (FAB, m/z) 243, 244, 245 (M+H)+.

المصدر