تفاعل #75846

معادلة التفاعل

2-cyanobenzaldehyde

tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate

→

title compound

2-{[(7bR,11aS)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-ylamino]methyl}benzonitrile

ظروف التفاعل

الإجراء التجريبي

Using 2-cyanobenzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 138. 1H NMR(CDCl3) δ: 8.42 (d, 1H), 7.67-7.50 (m, 3H), 7.19 (d, 1H, J=2.2 Hz), 6.98 (d, 1H, J=2.2 Hz), 5.32 (s, 2H), 4.65 (ABq, 2H), 4.20-4.15 (m, 1H), 3.83-3.77 (m, 1H), 3.62-3.57 (m, 1H), 3.50-3.45 (m, 1H), 3.28 (dd, 1H), 3.20 (dd, 1H), 3.03-2.96 (m, 2H), 2.90-2.78 (m, 2H), 2.05-1.98 (m, 2H).

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