تفاعل #7577

معادلة التفاعل

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

المردود 47.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 4 hours
3. 3
   درجة الحرارةto cool
4. 4
   استخلاصextracted with ethyl acetate (100 ml)
5. 5
   استخلاصThe ethyl acetate extract
6. 6
   تجفيفwas dried (MgSO4)
7. 7
   أخرىthe solvent removed by evaporation

الإجراء التجريبي

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

المصدر