تفاعل #75704

معادلة التفاعل

HCl

2-Methylthioquinoline-4-carboxylic acid methyl ester

sodium hydroxide

→

title compound

المردود 104.2%

2-Methylthioquinoline-4-carboxylic acid

المردود 104.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISSOLUTIONhad dissolved
2. 2
   أخرىThe precipitated solid was separated by filtration
3. 3
   أخرىdried

الإجراء التجريبي

2-Methylthioquinoline-4-carboxylic acid methyl ester (0.40 g) in methanol:2N sodium hydroxide (2:1, 45 ml) was heated at 60° C. until all solid had dissolved. Volume of solvent was reduced to (15 ml) at reduced pressure and acidified with 2N HCl (16 ml). The precipitated solid was separated by filtration and dried to give the title compound (0.39 g). 1H NMR δ: 2.68 (3H, s), 7.56 (1H, m), 7.75-7.80 (2H, m), 7.96 (1H, d, J=8.2 Hz), 8.55 (1H, d), 13.91 (1H, brs).

المصدر