تفاعل #75648

معادلة التفاعل

sodium hydroxide

3,5-dichloroaniline

ethylglyoxalate

styrene

trifluoroacetic acid

→

Compound 15

5,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

المذيبات

ethanol

acetonitrile

ظروف التفاعل

الإجراء التجريبي

Compound 15 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol styrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

المصدر