تفاعل #75607

معادلة التفاعل

sodium hydroxide

4-piperidinecarboxamide

benzyl chloride

potassium carbonate

→

1-benzyl-4-piperidine carboxamide

المردود 49.7%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىwas returned to room temperature
2. 2
   استخلاصit was extracted with ethyl acetate
3. 3
   غسيلThe organic layer was washed with brine
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   أخرىevaporated
6. 6
   غسيلThe resulting crystalline residue was washed with hexane/ethyl acetate
7. 7
   ترشيحcollected by filtration

الإجراء التجريبي

A mixture of 15 g 4-piperidinecarboxamide, 16.3 g benzyl chloride, 32.3 g potassium carbonate and 200 ml N,N-dimethylformamide was stirred at 80° C. for 4 hr. The reaction solution was returned to room temperature, and aqueous sodium hydroxide was added thereto, and then it was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and then evaporated. The resulting crystalline residue was washed with hexane/ethyl acetate and collected by filtration. 12.7 g of 1-benzyl-4-piperidine carboxamide was obtained as white flaky crystals.

المصدر