تفاعل #75590

معادلة التفاعل

potassium hydrogen fluoride

benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

→

title compound

المردود 87.0%

Benzyl 4-fluoromethyl-4-hydroxy-1-piperidinecarboxylate

المردود 87.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   ترشيحit was filtered through Celite
3. 3
   أخرىThe filtrate was evaporated

الإجراء التجريبي

3.2 g of potassium hydrogen fluoride and 610 mg tetra-n-butyl ammonium dihydrogen trifluoride were added to 5 g of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, and it was stirred at 120° C. for 7 hr. After cooling, methylene chloride was added thereto and it was filtered through Celite. The filtrate was evaporated, and the resulting residue was subjected to silica gel column chromatography to give 4.7 g of the title compound.

المصدر