تفاعل #75579

معادلة التفاعل

potassium-t-butoxide

N-(3-formyl-4-methoxybenzyl)phthalimide

→

N-(4-methoxy-3-vinylbenzyl)phthalimide

المردود 39.5%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction solution was filtered through Celite
2. 2
   أخرىevaporated
3. 3
   أخرىThe resulting residue was purified by silica gel column chromatography

الإجراء التجريبي

3.99 g of potassium-t-butoxide was added to 80 ml solution of 12.7 g methyltriphenyl phosphonium bromide in tetrahydrofuran at 0° C., 7 g of N-(3-formyl-4-methoxybenzyl)phthalimide was added thereto, and the mixture was stirred at room temperature for 1 hr. The reaction solution was filtered through Celite, and then evaporated. The resulting residue was purified by silica gel column chromatography to give 2.75 g of N-(4-methoxy-3-vinylbenzyl)phthalimide.

المصدر