تفاعل #75545

معادلة التفاعل

4-hydroxy-3-methoxy-2-nitro-benzaldehyde

(R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

→

(R)-6-{4-[N′-(4-Hydroxy-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl }-5-methyl-4,5-dihydro-2H-pyridazin-3-one

المذيبات

ethanol

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture refluxed for two hours
2. 2
   ترشيحThe resulting crystals were filtered at room temperature
3. 3
   غسيلwashed with ethanol

الإجراء التجريبي

A solution of 4-hydroxy-3-methoxy-2-nitro-benzaldehyde (1.6 g) in ethanol (15 ml) was added to a suspension of (R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (1.75 g) in ethanol (20 ml) and the resulting mixture refluxed for two hours. The resulting crystals were filtered at room temperature and washed with ethanol. Yield 2.37 g. HPLC: purity 99.4%, optical purity 99.8%.

المصدر