تفاعل #75482

معادلة التفاعل

4-amino-2-nitrophenol

nitric acid

cyanamide

→

title compound

المردود 54.0%

N-(4-Hydroxy-2-nitro-phenyl)-guanidine nitrate

المردود 54.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was refluxed under N2 for 22 h
2. 2
   أخرىThe solvent was evaporated
3. 3
   غسيلThe dark brown solid residue was washed with EtOH
4. 4
   أخرىwas dried under high vacuum

الإجراء التجريبي

A mixture of 4-amino-2-nitrophenol (25 mmol, 3.85 g) in EtOH (6 mL) on an ice bath was treated with nitric acid (69% aq soln.; 1.8 mL). To this of cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 22 h. The solvent was evaporated. The dark brown solid residue was washed with EtOH and was dried under high vacuum to afford the title compound as a grey solid (3.53 g, 54%).

المصدر