تفاعل #75478

معادلة التفاعل

4-fluoroaniline

Nitric acid

cyanamide

→

title compound

المردود 47.0%

N-(4-Fluoro-phenyl)-guanidine nitrate

المردود 47.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was refluxed under N2 for 21 h
2. 2
   أخرىThe solvent was evaporated to dryness
3. 3
   غسيلThe solid residue was washed with EtOH
4. 4
   أخرىdried under high vacuum overnight

الإجراء التجريبي

A solution of 4-fluoroaniline (25 mmol, 2.80 g) in EtOH (10 mL) was cooled on an ice bath. Nitric acid (69% aq. soln.; 1.8 mL) was added dropwise. Then cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 21 h. The solvent was evaporated to dryness. The solid residue was washed with EtOH and dried under high vacuum overnight to afford the title compound as a purple powder (2.54 g, 47%). This material was used for subsequent reaction without further purification.

المصدر