تفاعل #75220

معادلة التفاعل

glyoxylic acid

ammonium acetate

phenol

→

DL-p-hydroxyphenylglycine

المردود 28.9%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 41 hours
3. 3
   أخرىThe crystalline precipitates
4. 4
   ترشيحare collected by filtration
5. 5
   درجة الحرارةunder cooling
6. 6
   غسيلsuccessively washed with water and methanol

الإجراء التجريبي

30 g of an aqueous 40% glyoxylic acid solution are added to 70 ml of water, and 37.5 g of ammonium acetate and 22.5 g of phenol are added thereto under stirring. The mixture is stirred at room temperature for 41 hours. The crystalline precipitates are collected by filtration under cooling, and then successively washed with water and methanol. 7.8 g of DL-p-hydroxyphenylglycine are thereby obtained as white crystals. Yield: 28.9%, M.p. 225°-228° C. (decomp.).

المصدر