تفاعل #75202

معادلة التفاعل

1-[3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoyl]-L-proline tert-butyl ester

Trifluoromethanesulfonic acid

→

1-[3-mercapto-2-(methylthio)propanoyl]-L-proline

المذيبات

dichloromethane

anisole

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent is removed in vacuo
2. 2
   غسيلThe organic layer is washed six times with water
3. 3
   أخرىdried
4. 4
   تركيزconcentrated to dryness in vacuo

الإجراء التجريبي

1-[3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoyl]-L-proline tert-butyl ester (0.5 g.) is dissolved in a mixture of dichloromethane (2 ml.) and anisole (1.1 ml.) under a blanket of argon in an ice bath. Trifluoromethanesulfonic acid (1 g.) is added and the mixture is stirred at room temperature for thirty minutes. The solvent is removed in vacuo and the residue is distributed between water and ethyl acetate. The organic layer is washed six times with water, dried and concentrated to dryness in vacuo to yield 1-[3-mercapto-2-(methylthio)propanoyl]-L-proline.

المصدر