تفاعل #75114

معادلة التفاعل

2,4-diamino-6-[3,6-dihydro-1(2H)-pyridyl]pyrimidine-3-oxide

methylene chloride

chloroformic acid butyl ester

→

dibutyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide

المذيبات

triethylamine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe mixture is treated with 45 ml
2. 2
   أخرىThe mixture obtained
3. 3
   غسيلis washed with water
4. 4
   استخلاصextracted with methylene chloride
5. 5
   أخرىevaporated under reduced pressure
6. 6
   أخرىThe residue is recrystallized from ethanol, there

الإجراء التجريبي

20 G. of 2,4-diamino-6-[3,6-dihydro-1(2H)-pyridyl]pyrimidine-3-oxide are mixed with 250 ml. of methylene chloride and 35 ml. of triethylamine, stirred and cooled to 5° C. The mixture is treated with 45 ml. of chloroformic acid butyl ester and stirred at room temperature for 6 hours. The mixture obtained is washed with water, extracted with methylene chloride and evaporated under reduced pressure. The residue is recrystallized from ethanol, there being obtained dibutyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 131°-132° C.

المصدر