تفاعل #7497

معادلة التفاعل

sodium hydride

ethyl 7-oxo-4-azepanecarboxylate

tert-butyl 2-bromobutanoate

→

diester

المردود 94.4%

ethyl 1-[1-(tert-butoxycarbonyl)propyl]-7-oxo-4-azepanecarboxylate

المردود 94.4%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith reflux condenser, magnetic stirrer
2. 2
   تركيزconcentrated to dryness
3. 3
   workup.ADDITIONthe residue was poured on ice/water and neutralised with solid ammonium chloride
4. 4
   استخلاصThe mixture was extracted three times with CH2Cl2
5. 5
   تجفيفthe combined organic phases were dried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated to dryness
8. 8
   أخرىThe residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15)

الإجراء التجريبي

In a 150 ml three necked flask fitted with reflux condenser, magnetic stirrer and dropping funnel under inert atmosphere, 5.09 g (27.5 mmoles, 1 eq) of ethyl 7-oxo-4-azepanecarboxylate 28 and 12.27 g (55 mmoles, 2 eq) of tert-butyl 2-bromobutanoate were dissolved in 70 ml of acetonitrile. The temperature was raised to 50° C. and 1.32 g (55 mmoles, 2 eq) of sodium hydride were added portionwise (exothermic). The mixture was stirred one more hour at 50° C. and concentrated to dryness, the residue was poured on ice/water and neutralised with solid ammonium chloride. The mixture was extracted three times with CH2Cl2, the combined organic phases were dried over magnesium sulfate, filtered and concentrated to dryness. The residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15) to give 8.5 g of pure diester 29, 69% yield.

المصدر