تفاعل #74908

معادلة التفاعل

5-chloro-1-indanone

nitric acid

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5-Chloro-6-nitro-1-indanone

ظروف التفاعل

المعالجة

1. 1
   أخرىremains between -10° and -15° C
2. 2
   workup.ADDITIONAfter the addition
3. 3
   workup.ADDITIONthe reaction solution is poured onto ice
4. 4
   أخرىthe precipitate which has separated out
5. 5
   ترشيحis filtered off
6. 6
   غسيلwashed with water
7. 7
   أخرىThe crude product of melting point 110°-113° is recrystallized from ethanol, whereby the melting point of the pure 5-chloro-6-nitro-1-indanone
8. 8
   أخرىrises to 126°-128° C.

الإجراء التجريبي

86.0 g (0.51 mole) of 5-chloro-1-indanone are introduced in portions into 540 ml of fuming nitric acid (d=1.54), cooled to -20° C., so that the temperature of the reaction mixture remains between -10° and -15° C. After the addition has ended, the mixture is subsequently stirred for 45 minutes at -15° to -20° C., the reaction solution is poured onto ice and the precipitate which has separated out is filtered off and washed with water. The crude product of melting point 110°-113° is recrystallized from ethanol, whereby the melting point of the pure 5-chloro-6-nitro-1-indanone rises to 126°-128° C.

المصدر