تفاعل #74907

معادلة التفاعل

thioacetic acid

KOH

water

2-bromo-5-chloro-1-indanone

→

5-Chloro-2-mercapto-1-indanone

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added
2. 2
   أخرىThe product which crystallizes after some time
3. 3
   ترشيحis filtered off
4. 4
   workup.ADDITIONintroduced, under nitrogen, into 35 ml of a 5% strength aqueous NaOH solution
5. 5
   workup.STIRRINGAfter stirring for 1 hour at room temperature
6. 6
   ترشيحthe crystalline precipitate is filtered off
7. 7
   أخرىdecomposes at 173°-175° C.

الإجراء التجريبي

A solution of 1.37 g (18 mmoles) of thioacetic acid in 30 ml of ethanol is neutralized exactly, in a nitrogen atmosphere, by the dropwise addition of a 40% strength aqueous KOH solution, and 3.7 g (15 mmoles) of 2-bromo-5-chloro-1-indanone (Example 1 (a)) are added. The reaction mixture is stirred for 1 hour at room temperature and poured into 200 ml of water. The product which crystallizes after some time is filtered off and introduced, under nitrogen, into 35 ml of a 5% strength aqueous NaOH solution. After stirring for 1 hour at room temperature, the pH is adjusted to 1 with 2 N hydrochloric acid and the crystalline precipitate is filtered off. The resulting 5-chloro-2-mercapto-1-indanone decomposes at 173°-175° C.

المصدر