تفاعل #74835

معادلة التفاعل

p-chlorobenzonitrile

acetonitrile

sodium hydride

→

β-amino-4-chlorocinnamonitrile

المذيبات

water

ether

methanol

isopropanol

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONTo a mixture of 68.5 g
2. 2
   درجة الحرارةrefluxed on a steam bath for 6 hours
3. 3
   workup.STIRRINGstirred overnight at room temperature
4. 4
   ترشيحthe mixture is filtered
5. 5
   workup.DISSOLUTIONThe solid is dissolved in warm ethyl acetate
6. 6
   ترشيحfiltered
7. 7
   أخرىThe filtrate is evaporated to a solid

الإجراء التجريبي

To a mixture of 68.5 g. of p-chlorobenzonitrile and 24.0 g. of sodium hydride (50% in mineral oil) in 250 ml. of ether is added, 26.1 ml. of acetonitrile and 2 ml. of isopropanol. The mixture is stirred and refluxed on a steam bath for 6 hours and then stirred overnight at room temperature. A 5 ml. portion of methanol and 250 ml. of water are added. The ether is boiled away on a steam bath and the mixture is filtered. The solid is dissolved in warm ethyl acetate and filtered. The filtrate is evaporated to a solid giving β-amino-4-chlorocinnamonitrile.

المصدر