تفاعل #74788

معادلة التفاعل

2-dimethylaminomethyl-6-methoxy-1-tetralone hydrochloride

hydrochloric acid

potassium cyanide

→

2-cyanomethyl-6-methoxy-1-tetralone

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONintroduced below the surface of the liquid
2. 2
   درجة الحرارةThe mixture is refluxed for one hour
3. 3
   ترشيحfiltered

الإجراء التجريبي

13.5 g of 2-dimethylaminomethyl-6-methoxy-1-tetralone hydrochloride (C. A. 41, 6253 g) are dissolved in 200 ml of water and 4 ml of concentrated hydrochloric acid are added, followed by the concentrated aqueous solution of 6.5 g of potassium cyanide, introduced below the surface of the liquid. The mixture is refluxed for one hour, stirred at room temperature overnight and filtered, to yield the 2-cyanomethyl-6-methoxy-1-tetralone melting at 90°-93°. Similarly prepared are the following nitriles: 2-cyanomethyl-1-tetralone, b.p. 125°-30°/0.005 mm Hg; 2-cyanomethyl-6,7-dimethoxy-1-tetralone, m.p. 116°-118°; 2-cyanomethyl-7-methoxy-1-tetralone, m.p. 80°-84°: 2-cyanomethyl-5-methoxy-1-tetralone, m.p. 91°-94°.

المصدر