تفاعل #747726

معادلة التفاعل

5-(2-benzyloxy-4-iodomethylphenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one

2-benzyloxy-6-bromopyridine

1,2-dibromoethane

biphenyl

TMSCl

→

title compound

5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one

المذيبات

N,N-dimethylacetamide

N,N-dimethylacetamide

N,N-dimethylacetamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby heating under vacuum
2. 2
   درجة الحرارةcooled
3. 3
   درجة الحرارةthe mixture is heated until boiling
4. 4
   درجة الحرارةto cool
5. 5
   أخرىto produce a green solution
6. 6
   ترشيحThe organozinc solution is filtered
7. 7
   أخرىdegassed with N2
8. 8
   أخرىThe vessel is sealed
9. 9
   workup.STIRRINGthe reaction is stirred at 80° C. for 18 h
10. 10
    ترشيحthen is filtered through Celite
11. 11
    workup.ADDITIONThe resulting solution is diluted with EtOAc (10 mL)
12. 12
    غسيلwashed with water and brine
13. 13
    تجفيفdried over MgSO4
14. 14
    أخرىThe solvent is removed under reduced pressure
15. 15
    أخرىthe crude residue is purified by silica gel chromatography

الإجراء التجريبي

In a pressure vessel, zinc powder (429 mg, 6.6 mmol) is dried by heating under vacuum, then cooled, placed under N2, and slurried in N,N-dimethylacetamide (0.75 mL). To the slurry is added 1,2-dibromoethane (0.044 mL, 0.51 mmol) and the mixture is heated until boiling. The mixture is allowed to cool, and TMSCl (65 mL, 0.51 mmol) is added, followed by stirring for 30 min to produce a green solution. To the activated zinc is added 5-(2-benzyloxy-4-iodomethylphenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (600 mg, 1.1 mmol) in N,N-dimethylacetamide (1 mL) over 30 min. The organozinc solution is filtered and degassed with N2, then to it is added Pd2(dba)3 (50 mg, 0.055 mmol) and 2-di-t-butylphosphino)biphenyl (66 mg, 0.22 mmol), followed by degassed 2-benzyloxy-6-bromopyridine (350 mg, 1.3 mmol) in N,N-dimethylacetamide. The vessel is sealed and the reaction is stirred at 80° C. for 18 h. The reaction is allowed to cool to RT then is filtered through Celite. The resulting solution is diluted with EtOAc (10 mL) and washed with water and brine, then dried over MgSO4. The solvent is removed under reduced pressure and the crude residue is purified by silica gel chromatography using a gradient of 0-75% EtOAc/hexane to afford the title compound as a colorless oil: (M+H)+=616

المصدر