تفاعل #74764

معادلة التفاعل

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

potassium thiocyanate

→

2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was evaporated to dryness
2. 2
   استخلاصextracted with chloroform
3. 3
   تجفيفThe chloroform extracts were dried (MgSO4)
4. 4
   أخرىevaporated to a residue which
5. 5
   أخرىwas recrystallised from acetonitrile

الإجراء التجريبي

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°. (Found: C, 45.3; H, 5.3; N, 19.5; S, 29.3. C8H11N3S2 requires: C, 45.0; H, 5.2; N, 19.7; S, 30.1%).

المصدر