تفاعل #74759

معادلة التفاعل

ethyl 1-[N2 -(3-butoxy-2,4-dimethoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate acetate

NaOH

→

1-[N2 -(3-butoxy2,4-dimethoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid

المردود 79.6%

المذيبات

ethanol

water

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAt the end of this period, the reaction solvent was distilled off under reduced pressure at a temperature below 30° C
2. 2
   workup.DISSOLUTIONThe residue was dissolved in a small amount of water
3. 3
   أخرىto precipitate a white gummy substance
4. 4
   أخرىThe aqueous solution was separated by decantation
5. 5
   workup.DISSOLUTIONthe white precipitate was dissolved in 200 ml of chloroform
6. 6
   غسيلwashed with 30 ml of water
7. 7
   تجفيفdried over anhydrous sodium sulfate
8. 8
   أخرىUpon evaporation of solvent

الإجراء التجريبي

To a solution of 5.8 g of ethyl 1-[N2 -(3-butoxy-2,4-dimethoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate acetate in 80 ml of ethanol and 40 ml of water was added 10 ml of 2N NaOH aqueous solution at room temperature and stirring was continued overnight at room temperature. At the end of this period, the reaction solvent was distilled off under reduced pressure at a temperature below 30° C. The residue was dissolved in a small amount of water and then neutralized with 2N NCl to precipitate a white gummy substance. The aqueous solution was separated by decantation and the white precipitate was dissolved in 200 ml of chloroform, washed with 30 ml of water and then dried over anhydrous sodium sulfate. Upon evaporation of solvent, there was obtained 4.0 g (79%) of 1-[N2 -(3-butoxy2,4-dimethoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid in the form of an amorphous solid.

المصدر