تفاعل #74744

معادلة التفاعل

2-(2,2,2-Trifluoroethoxy)-5-nitropyridine

ammonium chloride

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product

المردود 23.1%

2-(2,2,2-Trifluoroethoxy)-3-Aminopyridine

المردود 23.1%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىno starting material (about 4 hours)
2. 2
   ترشيحThe reaction mixture was filtered
3. 3
   غسيلwashed with water, and solvents
4. 4
   أخرىremoved

الإجراء التجريبي

2-(2,2,2-Trifluoroethoxy)-5-nitropyridine (5.0 grams), powdered iron (15 grams), and ammonium chloride (25 grams) were refluxed in 3A ethanol until TLC detected no starting material (about 4 hours). The reaction mixture was filtered, washed with water, and solvents removed, yielding 1.0 gram of the product as a thin brownish liquid. NMR confirmed the identity of the product.

المصدر