تفاعل #74743

معادلة التفاعل

DMSO

2-Chloro-5-nitropyridine

2,2,2-trifluoroethanol

lithium hydroxide

→

2-(2,2,2-Trifluoroethoxy)-5-Nitropyridine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe product was separated by filtration
2. 2
   أخرىIt was crystallized from ethyl acetate-hexanes, yield 5.0 grams
3. 3
   أخرى35°-37° C.

الإجراء التجريبي

2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.

المصدر