تفاعل #74719

معادلة التفاعل

2-acetyl-2,3,5-trimethoxy-2,5-dihydrofuran

NaBH4

NH4Cl

→

2-(1-hydroxyethyl)-2,3,5-trimethoxy-2,5-dihydrofuran

المردود 100.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةmaintaining a temperature below 15° C
2. 2
   درجة الحرارةto warm to room temperature
3. 3
   استخلاصExtraction of the crude product
4. 4
   تركيزwith chloroform and concentration

الإجراء التجريبي

2-acetyl-2,3,5-trimethoxy-2,5-dihydrofuran (9.22 g, 0.049 moles) was dissolved in 100 ml of methanol and cooled to 0° C. Solid NaBH4 (4.0 g, 0.105 moles) was added portion-wise over 1 hour, maintaining a temperature below 15° C. The reaction was then allowed to warm to room temperature, and 20 ml of saturated aqueous NH4Cl added. Extraction of the crude product with chloroform and concentration yielded 9.3 g of 2-(1-hydroxyethyl)-2,3,5-trimethoxy-2,5-dihydrofuran (100%) as a clear 0.1, NMR (CDCl3 +D2O, δ) 5.5 (1H, m), 5.03 (1H, M), 3.8 (4H, m), 3.58 (3H, s), 3.3 (3H, s), 1.10 (3H, t).

المصدر