تفاعل #74648

معادلة التفاعل

HCl

2-iodo-4-(trifluoromethoxy)phenol

potassium carbonate

3-cyano-4-fluoro-N-[1,2,4]thiadiazol-5-yl-benzenesulfonamide

→

title compound

3-cyano-N-(1,2,4-thiadiazol-5-yl)-4-[2-iodo-4-(trifluoromethoxy)phenoxy]benzenesulfonamide

المذيبات

ethyl acetate

Dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was collected
2. 2
   غسيلwashed with brine (20 mL)
3. 3
   تجفيفdried over sodium sulphate
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe residue was triturated in dichloromethane
6. 6
   ترشيحfiltered

الإجراء التجريبي

To a suspension of 2-iodo-4-(trifluoromethoxy)phenol (Preparation 226, 600 mg, 1.97 mmol) and potassium carbonate (1125 mg, 8.14 mmol) in Dimethylsulfoxide (10 mL) was added 3-cyano-4-fluoro-N-[1,2,4]thiadiazol-5-yl-benzenesulfonamide (Preparation 65). The reaction was heated to 80° C. under N2 for 7 hours before the addition of ethyl acetate (20 mL) and 3M aqueous HCl solution (30 mL). The organic layer was collected, washed with brine (20 mL), dried over sodium sulphate and concentrated in vacuo. The residue was triturated in dichloromethane and filtered to afford 965 mg of the title compound.

المصدر