تفاعل #746282

معادلة التفاعل

2-Bromo-6-phenyl-pyridine

K2CO3

3-bromothiophenol

→

title compound

2-(3-Bromo-phenylsulfanyl)-6-phenyl-pyridine

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرى4×2 hours
2. 2
   أخرىat 130° C.
3. 3
   أخرىfollowed by 1×8 hours at 130° C
4. 4
   أخرىThe crude product was partially purified by column chromatography
5. 5
   غسيلeluting with 10% EtOAc in heptane

الإجراء التجريبي

2-Bromo-6-phenyl-pyridine (13) (100 mg, 0.43 mmol), K2CO3 (117 mg, 0.85 mmol) in acetone (2 mL) was added 3-bromothiophenol and the reaction mixture was heated in a CEM Discover microwave for 1×30 minutes at 90° C., then 4×2 hours at 130° C., followed by 1×8 hours at 130° C. The crude product was partially purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound. Yield: 100 mg, 68%; LC-MS tr 1.97 min; HPLC Purity: 55%; MS (ES+) m/z 342, 344 (M+H)

المصدر