تفاعل #74618

معادلة التفاعل

4-Aminopyrimidine

DABCO

3-chloro-4-fluorobenzenesulfonyl chloride

→

title compound

المردود 27.0%

3-Chloro-4-fluoro-N-pyrimidin-4-ylbenzenesulfonamide

المردود 27.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture immediately turned yellow and a precipitate was formed
2. 2
   تركيزthe mixture was concentrated in vacuo
3. 3
   workup.STIRRINGwater (75 mL) and stirred for 15 minutes
4. 4
   ترشيحThe resulting solid was filtered
5. 5
   أخرىdried in vacuo

الإجراء التجريبي

4-Aminopyrimidine (1.0 g, 10.5 mmol) and DABCO™ (1.18 g, 10.5 mmol) were added concurrently to a solution of 3-chloro-4-fluorobenzenesulfonyl chloride (1.25 mL, 10.0 mmol) in anhydrous acetonitrile (49 mL). The reaction mixture immediately turned yellow and a precipitate was formed. After stirring for 16 hours, the mixture was concentrated in vacuo. The crude material was suspended in ethyl acetate (75 mL) and water (75 mL) and stirred for 15 minutes. The resulting solid was filtered and dried in vacuo to afford the title compound, 0.83 g, 27% yield.

المصدر