تفاعل #745262

معادلة التفاعل

sodium hydroxide

Cyclohexanecarboxaldehyde

diethylamine hydrochloride

acetic acid

→

cyclohexylmethyl-ethyl-amine

المردود 83.8%

المذيبات

methylene chloride

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture is separated
2. 2
   غسيلthe organic layer is washed with a saturated brine
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   تركيزthe mixture is concentrated under reduced pressure

الإجراء التجريبي

Cyclohexanecarboxaldehyde (38 g), diethylamine hydrochloride (55 g) and acetic acid (29 ml) are dissolved in methylene chloride (500 ml) and thereto is added triacetoxy sodium borohydride (71.8 g) at room temperature and the mixture is stirred at room temperature overnight. To the reaction solution are added a 2N-aqueous sodium hydroxide solution and methylene chloride, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and the mixture is concentrated under reduced pressure to give cyclohexylmethyl-ethyl-amine (40.1 g) as a crude product. MS (m/z): 142 [M+H]+

المصدر