تفاعل #74503

معادلة التفاعل

water

2,4-dichlorobenzoic acid

compound 80

2,4-dichlorobenzoic acid

bromine

→

title compound

المردود 187.5%

5-Bromo-2,4-dichlorobenzoic acid

المردود 187.5%

المذيبات

chlorosulfonic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to ambient temperature
2. 2
   أخرىThe resulting solid was isolated by filtration
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

المصدر