تفاعل #74496

معادلة التفاعل

4-bromo-1-hydroxy-2-naphthoic acid

compound 67

4-bromo-1-hydroxy-2-naphthoic acid

dimethyl sulfate

K2CO3

→

title compound

المردود 78.6%

Methyl 4-bromo-1-methoxy-2-naphthoate

المردود 78.6%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight
2. 2
   ترشيحThe solid was filtered
3. 3
   أخرىcondensed
4. 4
   أخرىto give a solid residue, which
5. 5
   أخرىwas recrystallized from EtOAc/hexanes

الإجراء التجريبي

A mixture of 4-bromo-1-hydroxy-2-naphthoic acid (compound 67, 24.7 g, 92.2 mmol), dimethyl sulfate (21.8 mL, 231 mmol), and K2CO3 (31.9 g, 231 mmol) in acetone (200 mL) was refluxed overnight. The solid was filtered, and the filtrate was condensed to give a solid residue, which was recrystallized from EtOAc/hexanes to afford the title compound (21.4 g, 78%) as a white solid.

المصدر