تفاعل #74495

معادلة التفاعل

Bromine

1-hydroxy-2-naphthoic acid

compound 66

1-hydroxy-2-naphthoic acid

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title compound

المردود 92.1%

4-Bromo-1-hydroxy-2-naphthoic acid

المردود 92.1%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe resulting solid was filtered
2. 2
   أخرىdried in vacuo

الإجراء التجريبي

Bromine (6.1 mL, 120 mmol) was added to a solution of 1-hydroxy-2-naphthoic acid (compound 66, 18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to yield the title compound (24.6 g, 92%) as a white solid.

المصدر