تفاعل #74423

معادلة التفاعل

water

4-(2-((S)-1-(4-fluorophenyl)ethylamino)-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl)benzoyl chloride

pyrrolidine

→

2-((S)-1-(4-fluorophenyl)ethylamino)-5-methyl-5-(4-(pyrrolidine-1-carbonyl)phenyl)thiazol-4(5H)-one

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was gradually warmed to ambient temp.
2. 2
   استخلاصthe aqueous layer was extracted with CH2Cl2 three times
3. 3
   تجفيفThe combined organic phases were dried over Na2SO4
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe crude product was purified by silica gel chromatography

الإجراء التجريبي

To a solution of 4-(2-((S)-1-(4-fluorophenyl)ethylamino)-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl)benzoyl chloride (0.100 g, 0.26 mmol) in CH2Cl2 (1 mL) in a 0° C. bath was added pyrrolidine (Aldrich, 0.063 ml, 0.77 mmol). The mixture was gradually warmed to ambient temp. and stirred for 40 min. The reaction mixture was then added to water (5 mL), and the aqueous layer was extracted with CH2Cl2 three times. The combined organic phases were dried over Na2SO4, and concentrated in vacuo. The crude product was purified by silica gel chromatography. MS: 426 (M+1).

المصدر