تفاعل #74254

معادلة التفاعل

8,8-dibromobicyclo[5.1.0]octane

methyl glycolate

aluminum

→

17

المردود 66.0%

methyl 2-bromocyclooct-1-en-3-glycolate

المردود 66.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe silver salts are filtered off through a sintered glass funnel
2. 2
   غسيلwashed with AcOEt
3. 3
   تركيزThe solution is concentrated under vacuum
4. 4
   أخرىto give a viscous brown oil which
5. 5
   أخرىis purified by chromatography on silica gel (cyclohexane/2-15% AcOEt)

الإجراء التجريبي

3.85 g of silver perchlorate (18.6 mmol) are added to a solution of 8,8-dibromobicyclo[5.1.0]octane 16 (2.5 g, 9.3 mmol) and methyl glycolate (6.35 ml, 83.9 mmol) dissolved in 5 ml of anhydrous toluene in a dry round-bottomed flask under Ar protected from light by an aluminum film. The reaction mixture is stirred at ambient temperature for 1 h 30 and then the silver salts are filtered off through a sintered glass funnel and washed with AcOEt. The solution is concentrated under vacuum to give a viscous brown oil which is purified by chromatography on silica gel (cyclohexane/2-15% AcOEt) to produce 17 in the form of a yellow oil (w=1.7 g, i.e. 66% yield).

المصدر