تفاعل #742290

معادلة التفاعل

water

tert-butyl[(1S)-2-hydroxy-1-methylethyl]carbamate

pivaloyl chloride

Et3N

→

(2S)-2-[(tert-butoxycarbonyl)-amino]-propyl pivalate

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic phase was separated
2. 2
   غسيلwashed with 10% aqueous citric acid
3. 3
   أخرىThe residue was purified by column chromatography on silica gel eluting with 92:8 PE/EtOAc

الإجراء التجريبي

To a solution of the commercially available tert-butyl[(1S)-2-hydroxy-1-methylethyl]carbamate (1.0 eq.) in DCM (0.19M), pivaloyl chloride (1.1 eq.) and Et3N (1.1 eq.) were added. The reaction mixture was stirred at RT for 48 h, then water was added and the organic phase was separated and washed with 10% aqueous citric acid. The residue was purified by column chromatography on silica gel eluting with 92:8 PE/EtOAc.

المصدر