تفاعل #742251

معادلة التفاعل

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

potassium hydroxide

→

colourless crystals

المردود 51.9%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid

المردود 51.9%

المذيبات

ethanol

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 28 hours
2. 2
   تركيزthe reaction mixture was concentrated
3. 3
   workup.ADDITIONThe residue was diluted with 500 ml HCl 2N
4. 4
   استخلاصextracted with ether
5. 5
   غسيلThe organic phase was washed with 2N HCl and water
6. 6
   أخرىdried
7. 7
   أخرىevaporated to dryness
8. 8
   أخرىThe resulting solid was recrystallized

الإجراء التجريبي

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

المصدر