تفاعل #742249

معادلة التفاعل

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThen the reaction mixture was heated to reflux
2. 2
   درجة الحرارةAfter refluxing for 31 hours the mixture
3. 3
   درجة الحرارةwas cooled down
4. 4
   أخرىevaporated to dryness
5. 5
   أخرىThe resulting dark oil was purified by chromatography
6. 6
   أخرىto yield a colourless oil

الإجراء التجريبي

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

المصدر