تفاعل #741805

معادلة التفاعل

3-methoxy-5-methylthio-4-propoxybenzyl chloride

sodium cyanide

→

3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile

المردود 95.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution was filtered
2. 2
   تركيزthe filtrate was concentrated under vacuum
3. 3
   أخرىThe residue was purified by flash column chromatography

الإجراء التجريبي

To 16 g of 3-methoxy-5-methylthio-4-propoxybenzyl chloride in 100 ml of dry DMF was added 5 g (0.10 mole) sodium cyanide. The mixture was stirred for about 48 hours at rom temperature under N2. The solution was filtered, and the filtrate was concentrated under vacuum. The residue was purified by flash column chromatography to yield 14.5 g of 3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile as an oil. (95% yield).

المصدر