تفاعل #741331

معادلة التفاعل

2-benzyloxycarbonylaminomethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano3-chromene

3-chromene

2-hydroxymethyl-2-methyl-4-(1,2-dihydro2-oxo-1-pyridyl)-6-cyano-3-chromene

2-CBZ-aminomethyl-2-methyl-6-cyano-4-chromanone

4-chromanol

1-benzyloxycarbonylamino-2-propanone

→

2-aminomethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano-3-chromene

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرى1 bar until the calculated amount of H2 has been absorbed
2. 2
   ترشيحThe mixture is filtered
3. 3
   أخرىthe solution is evaporated

الإجراء التجريبي

A solution of 1 g of 2-benzyloxycarbonylaminomethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano3-chromene [obtainable from 1-benzyloxycarbonylamino-2-propanone ("1-CBZ-2-propanone") via 2-CBZ-aminomethyl-2-methyl-6-cyano-4-chromanone, the corresponding 4-chromanol, the corresponding 3-chromene and the corresponding 3,4-epoxide] in 20 ml of dioxane is hydrogenated on 0.5 g of 5% Pd-carbon at 20° C. and 1 bar until the calculated amount of H2 has been absorbed. The mixture is filtered, the solution is evaporated and 2-aminomethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano-3-chromene is obtained.

المصدر