تفاعل #74047

معادلة التفاعل

4-(3-mercaptopyridin-2-yl)benzonitrile

ethyl 2-bromo-2-methylpropanoate

K2CO3

→

ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate

المردود 49.4%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلthe reaction mixture was washed with water
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   تجفيفThe organic layer was dried over MgSO4
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by chromatography

الإجراء التجريبي

A mixture of 4-(3-mercaptopyridin-2-yl)benzonitrile (0.18 g, 0.85 mmol), ethyl 2-bromo-2-methylpropanoate (0.195 g, 1 mmol), and K2CO3 (0.138 g, 1.0 mmol) in DMF (2 mL) was stirred at room temperature for 2 hours. After the reaction was completed, the reaction mixture was washed with water and extracted with ethyl acetate. The organic layer was dried over MgSO4, concentrated and purified by chromatography to yield ethyl 2-(2-(4-cyanophenyl)pyridin-3-ylthio)-2-methylpropanoate (0.137 g, 49%).

المصدر