تفاعل #73998

معادلة التفاعل

4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

potassium carbonate

2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethanamine

(S)-pyrrolidine-2-carboxylic acid

intermediate 1.4

4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

→

N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline

المذيبات

DMSO

—

ice water

ظروف التفاعل

المعالجة

1. 1
   أخرىInto a 10-mL round-bottom flask purged
2. 2
   درجة الحرارةmaintained with an inert atmosphere of nitrogen
3. 3
   workup.STIRRINGAfter stirring overnight the reaction mixture
4. 4
   درجة الحرارةwas cooled with a water/ice bath
5. 5
   استخلاصThe resulting solution was extracted with 3×30 mL of ethyl acetate
6. 6
   غسيلwashed with 2×20 mL of brine
7. 7
   تجفيفThe mixture was dried over anhydrous sodium sulfate
8. 8
   تركيزconcentrated under vacuum
9. 9
   أخرىThis resulted in 130 mg (24%) of N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzenamine as yellow oil

الإجراء التجريبي

Into a 10-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline (intermediate 1.4) (400 mg, 1.08 mmol, 1.00 equiv) in DMSO (6 mL), 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethanamine (236.11 mg, 1.08 mmol, 1.00 equiv), (S)-pyrrolidine-2-carboxylic acid (24.79 mg, 0.21 mmol, 0.20 equiv), copper(I) iodide (20.48 mg, 0.11 mmol, 0.10 equiv) and potassium carbonate (223.18 mg, 1.62 mmol, 1.50 equiv). The resulting solution was stirred at 90° C. in an oil bath and the reaction progress was monitored by LCMS. After stirring overnight the reaction mixture was cooled with a water/ice bath and then diluted with ice water. The resulting solution was extracted with 3×30 mL of ethyl acetate and the organic extracts were combined and washed with 2×20 mL of brine. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (2:1). This resulted in 130 mg (24%) of N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzenamine as yellow oil.

المصدر