تفاعل #73970

معادلة التفاعل

(E)-ethyl 3-(4-(4-(N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)sulfamoyl)phenoxy)-3,5-difluorophenyl)-2-methylacrylate

trimethylphosphine

→

title compound

المردود 101.0%

(E)-ethyl 3-(4-(4-(N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)sulfamoyl)phenoxy)-3,5-difluorophenyl)-2-methylacrylate

المردود 101.0%

المذيبات

THF

water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvents were removed at reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (5 mL)
3. 3
   استخلاصextracted with EtOAc (3×25 mL)
4. 4
   تجفيفThe combined organic layers were dried (Na2SO4)
5. 5
   تركيزconcentrated

الإجراء التجريبي

To a solution of (E)-ethyl 3-(4-(4-(N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)sulfamoyl)phenoxy)-3,5-difluorophenyl)-2-methylacrylate (169 mg, 0.28 mmol) in THF (6 ml) and water (0.6 mL) under nitrogen was added trimethylphosphine (26 mg, 0.34 mmol). After stirring for 3 hours, the solvents were removed at reduced pressure and. The residue was dissolved in water (5 mL) and extracted with EtOAc (3×25 mL). The combined organic layers were dried (Na2SO4) and concentrated to give the title compound (162 mg).

المصدر