تفاعل #7397

معادلة التفاعل

(2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoic acid

3-methylpiperidine

→

title compound

المردود 27.3%

6-Chloro-N-{(3S)-1-[(1S)-1-methyl-2-(3-methylpiperidin-1-yl)-2-oxoethyl]-2-oxopyrrolidin-3-yl}naphthalene-2-sulfonamide

المردود 27.3%

المذيبات

N,N-diisopropylethylamine

DCM

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe filtrate collected
2. 2
   غسيلthe resin washed with DCM
3. 3
   تركيزThe combined DCM solutions were concentrated under reduced pressure
4. 4
   أخرىthe residue purified by mass

الإجراء التجريبي

To polymer N-cyclohexylcarbodiimide-N′-propyloxymethyl polystyrene (0.038 g) in an Alltech™ tube was added a solution of (2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoic acid (0.007 g) in DCM (0.9 ml) followed by 3-methylpiperidine (0.0025 g) in DMF (0.1 ml) and N,N-diisopropylethylamine (0.006 ml). The mixture was shaken at room temperature for 4 days. The tube was drained, the filtrate collected and the resin washed with DCM. The combined DCM solutions were concentrated under reduced pressure and the residue purified by mass directed preparative h.p.l.c. to give the title compound (0.0023 g) as a white solid.

المصدر