تفاعل #73969
ord-199563e105234712aa9009e8a9abcee2
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1استخلاصthe reaction mixture was extracted with DCM (2×25 mL)
- 2غسيلThe combined orgaic layers were washed with water (10 mL), brine (10 mL)
- 3تجفيفdried (Na2SO4)
- 4تركيزconcentrated
- 5أخرىThe crude material was purified by flash chromatography on silica gel eluting with 50% EtOAc in DCM
الإجراء التجريبي
To a solution of (E)-ethyl 3-(4-(4-(chlorosulfonyl)phenoxy)-3,5-difluorophenyl)-2-methylacrylate (intermediate 41.3) (250 mg, 0.60 mmol) in DCM (3 mL) was added a solution of 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethanamine (157 mg, 0.72 mmol) and triethylamine (72 mg, 0.72 mmol) in DCM (2 mL). After 15 minutes, water (10 mL) was added and the reaction mixture was extracted with DCM (2×25 mL). The combined orgaic layers were washed with water (10 mL), brine (10 mL), dried (Na2SO4) and concentrated. The crude material was purified by flash chromatography on silica gel eluting with 50% EtOAc in DCM to give the title compound (169 mg).